Methanol → HCID 823415, compound

HRID 2075742Notes

Reaction equation

HRID 2075742 reaction equation
[C:1]1([N:7]2[C:11](=[O:12])[C:10]3=[CH:13][C:14]([C:17](Cl)=[O:18])=[CH:15][CH:16]=[C:9]3[C:8]2=[O:20])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:21][OH:22]>>[C:1]1([N:7]2[C:11](=[O:12])[C:10]3=[CH:13][C:14]([C:17]([O:22][CH3:21])=[O:18])=[CH:15][CH:16]=[C:9]3[C:8]2=[O:20])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 25179628HCID 25179628, compound

Product 1

HCID 823415HCID 823415, compoundYield 94.7%

Procedure

A mixture of 137 g of N-phenyl-4-chlorocarbonylphthalimide and methanol (1.37 L) was refluxed for 1 hr. The solid which formed on cooling was collected and dried to afford 128 g (94.7%) of N-phenyl-4-carbomethoxyphthalimide, Compound 1, mp 200-207° C. Recrystallization of 91.3 g from 2 L of acetonitrile yielded 77.8 g (80.7%) of Compound 1, mp 205-207° C.

Workup

  1. temperaturewas refluxed for 1 hr
  2. customThe solid which formed
  3. temperatureon cooling
  4. customwas collected
  5. customdried

Sources & evidence

ORD record
ord-9d2f3cb9f3744e619ef72b939657c93e
Source dataset
uspto-grants-2011_04
Patent number
US07923184B2

Reaction notes

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