HRID2075765

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1512537

(3S)-4-(tert-Butoxycarbonyl)morpholine-3-carboxylic acid

C10H17NO5

结构：CC(C)(C)OC(=O)N1CCOCC1C(=O)Nc1ccc(C#Cc2cn(CCO)nc2-c2cc(Cl)ccc2O)cc1

HCID135974911

未命名化合物

结构：Nc1ccc(C#Cc2cn(CCO)nc2-c2cc(Cl)ccc2O)cc1

HCID135974913

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCOC[C@H]1C(=O)Nc1ccc(C#Cc2cn(CCO)nc2-c2cc(Cl)ccc2O)cc1

HCID135975009

未命名化合物

PROCEDURE

实验过程

Using the same procedure for the preparation of 16A, reaction of compound 2A with (S)-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester (19A) afforded the title compound 20A as a white powder in similar yield. Its 1H NMR and LCMS data are identical with those of compound 16A.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-122a840df021442a90ffe4d14e885f40
来源数据集: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07923004B2
来源说明: uspto-grants-2011_04

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH:9]1[C:14](=[O:40])[NH:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]#[C:23][C:24]2[C:25]([C:32]3[CH:37]=[C:36]([Cl:38])[CH:35]=[CH:34][C:33]=3[OH:39])=[N:26][N:27]([CH2:29][CH2:30][OH:31])[CH:28]=2)=[CH:18][CH:17]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].NC1C=CC(C#CC2C(C3C=C(Cl)C=CC=3O)=NN(CCO)C=2)=CC=1.C(OC(N1CCOC[C@H]1C(O)=O)=O)(C)(C)C>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][C@H:9]1[C:14](=[O:40])[NH:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]#[C:23][C:24]2[C:25]([C:32]3[CH:37]=[C:36]([Cl:38])[CH:35]=[CH:34][C:33]=3[OH:39])=[N:26][N:27]([CH2:29][CH2:30][OH:31])[CH:28]=2)=[CH:20][CH:21]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]