HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3S)-4-(tert-Butoxycarbonyl)morpholine-3-carboxylic acid → 3(S)-{4-[3-(5-Chloro-2-hydroxy-phenyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-morpholine-4-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3S)-4-(tert-Butoxycarbonyl)morpholine-3-carboxylic acid | HCID 1512537 | — |
| Reactant | 3(R,S)-{4-[3-(5-Chloro-2-hydroxy-phenyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-morpholine-4-carboxylic acid tert-butyl ester | HCID 135974911 | — |
| Reactant | HCID 135974913 | HCID 135974913 | — |
| Product | 3(S)-{4-[3-(5-Chloro-2-hydroxy-phenyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-morpholine-4-carboxylic acid tert-butyl ester | HCID 135975009 | — |
Reaction Steps
Using the same procedure for the preparation of 16A, reaction of compound 2A with (S)-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester (19A) afforded the title compound 20A as a white powder in similar yield. Its 1H NMR and LCMS data are identical with those of compound 16A.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07923004B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-122a840df021442a90ffe4d14e885f40 |
| Source note | uspto-grants-2011_04 |