HCID 136202009, compound → HCID 136331516, compound

HRID 2075970Notes

Reaction equation

HRID 2075970 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([C:17]2[C:22]([C:23]3[N:27]=[C:26]([CH3:28])[O:25][N:24]=3)=[CH:21][C:20]([O:29][CH3:30])=[C:19]([OH:31])[C:18]=2[N+:32]([O-:34])=[O:33])=[O:16])=[CH:11][CH:10]=1)C1C=CC=CC=1>Br.C(O)(=O)C>[OH:31][C:19]1[C:18]([N+:32]([O-:34])=[O:33])=[C:17]([C:15]([C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=2)=[O:16])[C:22]([C:23]2[N:27]=[C:26]([CH3:28])[O:25][N:24]=2)=[CH:21][C:20]=1[O:29][CH3:30]

Participants

3

Reactant 1

HCID 136202009HCID 136202009, compound

Product 1

HCID 136331516HCID 136331516, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 21893785Acetic Acid Mixture with Hydrobromic AcidSolvent

Procedure

A mixture of (4-benzyloxyphenyl)-[3-hydroxy-4-methoxy-6-(5-methyl-[1,2,4]oxadiazol-3-yl)-2-nitrophenyl]methanone (reference example 22-42) (395 mg) and a 25% hydrogen bromide-acetic acid solution (10 mL) was stirred at 45° C. for 2 hours. The mixture was concentrated under reduced pressure to give the title compound (310 mg).

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ed0cedf6af484dd799a5c1a5ee3ba838
Source dataset
uspto-grants-2011_04
Patent number
US07923462B2

Reaction notes

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