2-Bromo-6-(2-methoxy-phenyl)-cyclohexanone → [3-Fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-[4-(2-methoxy-phenyl)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-amine

HRID 2076032Notes

Reaction equation

HRID 2076032 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:14][C:15]([NH2:17])=[S:16])[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]1.Br[CH:19]1[CH2:24][CH2:23][CH2:22][CH:21]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[O:31][CH3:32])[C:20]1=O>>[F:1][C:2]1[CH:3]=[C:4]([NH:14][C:15]2[S:16][C:19]3[CH2:24][CH2:23][CH2:22][CH:21]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=4[O:31][CH3:32])[C:20]=3[N:17]=2)[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]1

Participants

3

Reactant 2

HCID 670958932-Bromo-6-(2-methoxy-phenyl)-cyclohexanoneHCID 86632602[3-Fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-thiourea

Product 1

HCID 44193855[3-Fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-[4-(2-methoxy-phenyl)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-amine

Procedure

The title compound was prepared from [3-fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-thiourea (45 mg, 0.18 mmol) and crude 2-bromo-6-(2-methoxy-phenyl)-cyclohexanone (153 mg, 0.50 mmol) using in analogous manner the procedure described in example 1b). Obtained as a light-yellow solid (14 mg, 18%). MS ISP (m/e): 435.4 [(M+H)+]. mp 227-230° C.

Sources & evidence

ORD record
ord-141864308e96412aa7e22ad59719ca30
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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