2-Bromo-6-(2-methoxy-phenyl)-cyclohexanone → [3-Fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-[4-(2-methoxy-phenyl)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-amine

Participants

Reaction Steps

The title compound was prepared from [3-fluoro-4-(4-methyl-imidazol-1-yl)-phenyl]-thiourea (45 mg, 0.18 mmol) and crude 2-bromo-6-(2-methoxy-phenyl)-cyclohexanone (153 mg, 0.50 mmol) using in analogous manner the procedure described in example 1b). Obtained as a light-yellow solid (14 mg, 18%). MS ISP (m/e): 435.4 [(M+H)+]. mp 227-230° C.

Provenance & Evidence