tert-Butoxy bis(dimethylamino)methane → [1-(4-Chloro-phenyl)-3-[1-dimethylamino-methylidene]-2-oxo-cyclohexyl]-acetonitrile

HRID 2076058Notes

Reaction equation

HRID 2076058 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:15][C:16]#[N:17])[CH2:13][CH2:12][CH2:11][CH2:10][C:9]2=[O:14])=[CH:4][CH:3]=1.C(O[CH:23](N(C)C)[N:24]([CH3:26])[CH3:25])(C)(C)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([CH2:15][C:16]#[N:17])[CH2:13][CH2:12][CH2:11][C:10](=[CH:23][N:24]([CH3:26])[CH3:25])[C:9]2=[O:14])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 68911510[1-(4-Chlorophenyl)-2-oxo-cyclohexyl]-acetonitrile

Product 1

HCID 67096051[1-(4-Chloro-phenyl)-3-[1-dimethylamino-methylidene]-2-oxo-cyclohexyl]-acetonitrile

Procedure

[1-(4-Chlorophenyl)-2-oxo-cyclohexyl]-acetonitrile (101 mg, 0.43 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 45a) to give crude title compound (149 mg) as a red oil which was used directly in the next step.

Sources & evidence

ORD record
ord-8ba4e7165850462189fcbaed7dafea47
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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