tert-Butoxy bis(dimethylamino)methane → Ethyl 3-[1-dimethylamino-methylidene]-2-oxo-cyclohexanecarboxylate

HRID 2076061Notes

Reaction equation

HRID 2076061 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[C:8]([O:10][CH2:11][CH3:12])=[O:9].C(O[CH:18](N(C)C)[N:19]([CH3:21])[CH3:20])(C)(C)C>>[CH3:18][N:19]([CH3:21])[CH:20]=[C:7]1[CH2:6][CH2:5][CH2:4][CH:3]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:2]1=[O:1]

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 95543Ethyl 2-oxocyclohexanecarboxylate

Product 1

HCID 67096118Ethyl 3-[1-dimethylamino-methylidene]-2-oxo-cyclohexanecarboxylate

Procedure

Ethyl 2-oxo-cyclohexanecarboxylate (38 mg, 0.22 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 45a) to give crude title compound (49 mg) as a yellow oil which was used directly in the next step. MS ISP (m/e): 226.1 [(M+H)+].

Sources & evidence

ORD record
ord-25f8234a8d644ff2a1f01d8c715b06d8
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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