HCID 67096271, compound → HCID 57780687, compound

HRID 2076074Notes

Reaction equation

HRID 2076074 reaction equation
C([C:3]1([C:15]2[CH:20]=[C:19]([Cl:21])[CH:18]=[CH:17][C:16]=2[Cl:22])[CH2:9][CH2:8][CH2:7][CH2:6][C:5](=[CH:10]N(C)C)[C:4]1=O)C.[N+]([O-])(O)=O.[N+]([O-])(O)=O.[CH3:31][O:32][C:33]1[CH:34]=[C:35]([NH:45][C:46]([NH2:48])=[NH:47])[CH:36]=[CH:37][C:38]=1[N:39]1[CH:43]=[C:42]([CH3:44])[N:41]=[CH:40]1>>[Cl:22][C:16]1[CH:17]=[CH:18][C:19]([Cl:21])=[CH:20][C:15]=1[CH:3]1[C:4]2[N:48]=[C:46]([NH:45][C:35]3[CH:36]=[CH:37][C:38]([N:39]4[CH:43]=[C:42]([CH3:44])[N:41]=[CH:40]4)=[C:33]([O:32][CH3:31])[CH:34]=3)[N:47]=[CH:10][C:5]=2[CH2:6][CH2:7][CH2:8][CH2:9]1

Participants

3

Reactant 2

HCID 67096271HCID 67096271, compoundHCID 178493228HCID 178493228, compound

Product 1

HCID 57780687HCID 57780687, compound

Procedure

The title compound was prepared from crude ethyl 2-(2,5-dichloro-phenyl)-7-[1-dimethylamino-methylidene]-cycloheptanone (197 mg, ca. 0.61 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (169 mg, 0.45 mmol) using in analogous manner the procedure described in example 45b). Obtained as a pale-yellow solid (163 mg, 73%). MS ISP (m/e): 494.0 [(M+H)+]. mp 218-220° C.

Sources & evidence

ORD record
ord-0af74c6671164c7d87455d209e83b95a
Source dataset
uspto-grants-2011_04
Patent number
US07923450B2

Reaction notes

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