Trifluoroacetic acid → HCID 135507450, compound

HRID 2076239Notes

Reaction equation

C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:25]=[CH:24][N:23]4[C:26]([C:30]([NH:32][CH3:33])=[O:31])=[C:27]([CH3:29])[N:28]=[C:22]4[CH:21]=3)=[CH:14][CH:15]=[N:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1.C(O)(C(F)(F)F)=O>>[OH:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:25]=[CH:24][N:23]4[C:26]([C:30]([NH:32][CH3:33])=[O:31])=[C:27]([CH3:29])[N:28]=[C:22]4[CH:21]=3)=[CH:14][CH:15]=[N:16]2)=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 59730753HCID 59730753, compound

Product 1

HCID 135507450HCID 135507450, compound

Procedure

The first step of the reaction was carried out according to Scheme II discussed previously to yield 7-{[7-(benzyloxy)quinolin-4-yl]oxy}-N,2-dimethylimidazo[1,2-α]pyridine-3-carboxamide 111-C. Following the addition of TFA and reflux, 7-[(7-hydroxyquinolin-4-yl)oxy]-N,2-dimethylimidazo[1,2-α]pyridine-3-carboxamide 111 was obtained.

Workup

temperaturereflux

Sources & evidence

ORD record: ord-3fc8ef9f98eb4fdaaa96faaa92735bc2
Source dataset: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07923457B2

Reaction notes

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