HRID2076274

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：[CH3][Sn]([CH3])([CH3])[N]=[N+]=[N-]

HCID5104973

Azidotrimethyltin(IV)

C3H9N3Sn

反应SMILES：CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1

HCID10865273

Trityllosartan

C41H37ClN6O

PRODUCTS

产物

反应SMILES：CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1

HCID3961

Losartan

C22H23ClN6O

PROCEDURE

实验过程

Dupont/Merck in their patents and papers always described that trityl losartan of the formula (7) is detritylated to get Losartan. They have used trimethyl tin azide or tri alkyl tin azides for the preparation of tetrazoles. The trityl Losartan of the formula (7) is reacted with mineral acid to give Losartan of the formula (1). The trityl Losartan of the formula (7) is prepared using trimethyl or trialkyl tin azide for the formation of tetrazole nucleus.