HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azido(trimethyl)stannane → Losartan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azido(trimethyl)stannane | HCID 5104973 | — |
| Reactant | Trityllosartan | HCID 10865273 | — |
| Product | Losartan | HCID 3961 | — |
Reaction Steps
Dupont/Merck in their patents and papers always described that trityl losartan of the formula (7) is detritylated to get Losartan. They have used trimethyl tin azide or tri alkyl tin azides for the preparation of tetrazoles. The trityl Losartan of the formula (7) is reacted with mineral acid to give Losartan of the formula (1). The trityl Losartan of the formula (7) is prepared using trimethyl or trialkyl tin azide for the formation of tetrazole nucleus.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07923566B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-33f438bac9234bd2ac3b6c20124e1fdf |
| Source note | uspto-grants-2011_04 |