Trityl chloride → HCID 178420198, compound

HRID 2076275Notes

Reaction equation

HRID 2076275 reaction equation
[NH:1]1[CH:5]=[N:4][N:3]=[N:2]1.[C:6](Cl)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[C:6]([C:5]1[NH:4][N:3]=[N:2][N:1]=1)([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 6456Trityl chlorideHCID 178418441HCID 178418441, compound

Product 1

HCID 178420198HCID 178420198, compound

Procedure

The compound of the formula (11) is prepared using tri alkyl tin azide. Ortho tolyl benzonitrile (OTBN of the formula (8) is reacted with trialkyl tin azide followed by hydrolysis to give tetrazole derivative of the formula (9). The tetrazole derivative is reacted with trityl chloride to give trityl tetrazole derivative of the formula (10), which on radical bromination gives compound of the formula (11). The reaction sequence is given in the Scheme 6.

Sources & evidence

ORD record
ord-a6ec1d6ef2ee4948937c33566120f999
Source dataset
uspto-grants-2011_04
Patent number
US07923566B2

Reaction notes

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