3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-N-(2-hydroxy-ethoxy)-benzamide → 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-[(2-methyl-2-methylcarbamoyl-propoxyimino)-methyl]-benzamide

HRID 20763Notes

Reaction equation

HRID 20763 reaction equation
[NH2:1][O:2][CH2:3][C:4]([CH3:10])([CH3:9])[C:5]([NH:7][CH3:8])=[O:6].[F:11][C:12]1[C:13]([NH:28][C:29]2[CH:34]=[CH:33][C:32]([I:35])=[CH:31][C:30]=2[F:36])=[C:14]([CH:22]=[C:23]([CH:26]=O)[C:24]=1[F:25])[C:15]([NH:17][O:18][CH2:19][CH2:20][OH:21])=[O:16]>>[F:11][C:12]1[C:13]([NH:28][C:29]2[CH:34]=[CH:33][C:32]([I:35])=[CH:31][C:30]=2[F:36])=[C:14]([CH:22]=[C:23]([CH:26]=[N:1][O:2][CH2:3][C:4]([CH3:10])([C:5](=[O:6])[NH:7][CH3:8])[CH3:9])[C:24]=1[F:25])[C:15]([NH:17][O:18][CH2:19][CH2:20][OH:21])=[O:16]

Participants

3

Reactant 2

HCID 231323883,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-N-(2-hydroxy-ethoxy)-benzamideHCID 553004123-aminooxy-2,2,N-trimethyl-propionamide

Product 1

HCID 722609183,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-[(2-methyl-2-methylcarbamoyl-propoxyimino)-methyl]-benzamide

Procedure

The title compound was synthesized as a mixture of E/Z geometric isomers, using the procedure described in Step C of Example 19, from 3-aminooxy-2,2,N-trimethyl-propionamide obtained in Step B and 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-N-(2-hydroxy-ethoxy-benzamide obtained in Step F of Example 1.

Sources & evidence

ORD record
ord-a758c5231ad94cbc816ee25b92892de5
Source dataset
uspto-grants-2010_06
Patent number
US07745663B2

Reaction notes

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