HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-N-(2-hydroxy-ethoxy)-benzamide → 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-[(2-methyl-2-methylcarbamoyl-propoxyimino)-methyl]-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-N-(2-hydroxy-ethoxy)-benzamide | HCID 23132388 | — |
| Reactant | 3-aminooxy-2,2,N-trimethyl-propionamide | HCID 55300412 | — |
| Product | 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-[(2-methyl-2-methylcarbamoyl-propoxyimino)-methyl]-benzamide | HCID 72260918 | — |
Reaction Steps
The title compound was synthesized as a mixture of E/Z geometric isomers, using the procedure described in Step C of Example 19, from 3-aminooxy-2,2,N-trimethyl-propionamide obtained in Step B and 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-N-(2-hydroxy-ethoxy-benzamide obtained in Step F of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745663B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-a758c5231ad94cbc816ee25b92892de5 |
| Source note | uspto-grants-2010_06 |