(3-Bromophenyl)acetic acid → HCID 67119206, compound

HRID 2076578Notes

Reaction equation

CC1(C)C(C)(C)OB([C:9]2[CH:33]=[CH:32][C:12]([O:13][CH2:14][C:15]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:16]=3[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:11][CH:10]=2)O1.Br[C:36]1[CH:37]=[C:38]([CH2:42][C:43]([OH:45])=[O:44])[CH:39]=[CH:40][CH:41]=1>>[C:20]([O:19][C:17]([C:16]1[CH:24]=[C:25]([C:28]([F:31])([F:29])[F:30])[CH:26]=[CH:27][C:15]=1[CH2:14][O:13][C:12]1[CH:32]=[CH:33][C:9]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([CH2:42][C:43]([OH:45])=[O:44])[CH:37]=2)=[CH:10][CH:11]=1)=[O:18])([CH3:23])([CH3:22])[CH3:21]

Participants

Reactant 2

HCID 74653(3-Bromophenyl)acetic acid

HCID 67119026HCID 67119026, compound

Product 1

HCID 67119206HCID 67119206, compound

Procedure

According to a method similar to Example (8-1), from tert-butyl 2-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl}-5-(trifluoromethyl)benzoate (88 mg, 0.18 mmol) obtained in Example (2-4) and 3-bromophenylacetic acid (50 mg, 0.23 mmol), the title compound was obtained as a yellow powder (4.5 mg, yield: 29%).

Sources & evidence

ORD record: ord-87a0a370ed2b4b459f8d60676233fef3
Source dataset: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07923573B2

Reaction notes

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