Methyl 2-(4-bromophenyl)acetate → HCID 67119171, compound

HRID 2076580Notes

Reaction equation

HRID 2076580 reaction equation
CC1(C)C(C)(C)OB([C:9]2[CH:33]=[CH:32][C:12]([O:13][CH2:14][C:15]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:16]=3[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:11][CH:10]=2)O1.Br[C:36]1[CH:41]=[CH:40][C:39]([CH2:42][C:43]([O:45][CH3:46])=[O:44])=[CH:38][CH:37]=1>>[CH3:46][O:45][C:43]([CH2:42][C:39]1[CH:40]=[CH:41][C:36]([C:9]2[CH:33]=[CH:32][C:12]([O:13][CH2:14][C:15]3[CH:27]=[CH:26][C:25]([C:28]([F:29])([F:30])[F:31])=[CH:24][C:16]=3[C:17]([O:19][C:20]([CH3:21])([CH3:23])[CH3:22])=[O:18])=[CH:11][CH:10]=2)=[CH:37][CH:38]=1)=[O:44]

Participants

3

Reactant 2

HCID 316783Methyl 2-(4-bromophenyl)acetateHCID 67119026HCID 67119026, compound

Product 1

HCID 67119171HCID 67119171, compoundYield 52%

Procedure

According to a method similar to Example (8-1), from tert-butyl 2-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl}-5-(trifluoromethyl)benzoate (100 mg, 0.21 mmol) obtained in Example (2-4) and methyl (4-bromophenyl)acetate (62 mg, 0.27 mmol) obtained in Example (3-1), tert-butyl 2-[({4′-[(methoxycarbonyl)methyl]-1,1′-biphenyl-4-yl}oxy)methyl]-5-(trifluoromethyl)benzoate was obtained (54 mg, yield: 52%).

Sources & evidence

ORD record
ord-aeea1902c2124fe0be5f86add77032bb
Source dataset
uspto-grants-2011_04
Patent number
US07923573B2

Reaction notes

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