[2-(Dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)phenyl]methanol → Allyl (4'-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-3-fluoro-1,1'-biphenyl-4-yl)acetate

HRID 2076599Notes

Reaction equation

HRID 2076599 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)[CH:5]=[CH:6][C:7]=1[CH2:8][C:9]([O:11][CH2:12][CH:13]=[CH2:14])=[O:10].[CH3:22][O:23][CH:24]([O:41][CH3:42])[C:25]1[C:30]([O:31][CH2:32][O:33][CH3:34])=[C:29]([C:35]([F:38])([F:37])[F:36])[CH:28]=[CH:27][C:26]=1[CH2:39]O>>[CH3:42][O:41][CH:24]([O:23][CH3:22])[C:25]1[C:30]([O:31][CH2:32][O:33][CH3:34])=[C:29]([C:35]([F:38])([F:37])[F:36])[CH:28]=[CH:27][C:26]=1[CH2:39][O:21][C:18]1[CH:17]=[CH:16][C:15]([C:4]2[CH:5]=[CH:6][C:7]([CH2:8][C:9]([O:11][CH2:12][CH:13]=[CH2:14])=[O:10])=[C:2]([F:1])[CH:3]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 67119352[2-(Dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)phenyl]methanolHCID 86088131Allyl (3-fluoro-4'-hydroxy-1,1'-biphenyl-4-yl)acetate

Product 1

HCID 86617399Allyl (4'-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-3-fluoro-1,1'-biphenyl-4-yl)acetate

Procedure

According to a method similar to Example (6-7), from allyl (3-fluoro-4′-hydroxy-1,1′-biphenyl-4-yl)acetate (3.10 g, 10.9 mmol) obtained in Example (11-3) and [2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)phenyl]methanol (3.70 g, 12.0 mmol) obtained in Example (6-6), allyl (4′-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-3-fluoro-1,1′-biphenyl-4-yl)acetate was obtained as a pale yellow oil (3.89 g, yield: 61%).

Sources & evidence

ORD record
ord-9dbe5f7080c0414abcbfdfd9819212df
Source dataset
uspto-grants-2011_04
Patent number
US07923573B2

Reaction notes

Loading…