[2-(Dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)phenyl]methanol → Allyl (4'-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-3-fluoro-1,1'-biphenyl-4-yl)acetate

Participants

Reaction Steps

According to a method similar to Example (6-7), from allyl (3-fluoro-4′-hydroxy-1,1′-biphenyl-4-yl)acetate (3.10 g, 10.9 mmol) obtained in Example (11-3) and [2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)phenyl]methanol (3.70 g, 12.0 mmol) obtained in Example (6-6), allyl (4′-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-3-fluoro-1,1′-biphenyl-4-yl)acetate was obtained as a pale yellow oil (3.89 g, yield: 61%).

Provenance & Evidence