4-Bromophenol → 1-[(4-Bromophenoxy)methyl]-2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzene

HRID 2076619Notes

Reaction equation

HRID 2076619 reaction equation
[CH3:1][O:2][CH:3]([O:20][CH3:21])[C:4]1[C:9]([O:10][CH2:11][O:12][CH3:13])=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:7]=[CH:6][C:5]=1[CH2:18][OH:19].[Br:22][C:23]1[CH:28]=[CH:27][C:26](O)=[CH:25][CH:24]=1>>[Br:22][C:23]1[CH:28]=[CH:27][C:26]([O:19][CH2:18][C:5]2[CH:6]=[CH:7][C:8]([C:14]([F:15])([F:16])[F:17])=[C:9]([O:10][CH2:11][O:12][CH3:13])[C:4]=2[CH:3]([O:2][CH3:1])[O:20][CH3:21])=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 78084-BromophenolHCID 67119352[2-(Dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)phenyl]methanol

Product 1

HCID 671190361-[(4-Bromophenoxy)methyl]-2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzeneYield 77%

Procedure

According to a method similar to Example (6-7), from [2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)phenyl]methanol (3.00 g, 9.66 mmol) obtained in Example (6-6) and 4-bromophenol (2.00 g, 11.6 mmol), 1-[(4-bromophenoxy)methyl]-2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzene was obtained (3.46 g, yield: 77%).

Sources & evidence

ORD record
ord-4b5a8de8c33546479c81e66dd5d4680a
Source dataset
uspto-grants-2011_04
Patent number
US07923573B2

Reaction notes

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