Methyl (2-ethyl-4'-hydroxy-1,1'-biphenyl-4-yl)acetate → Methyl (2-ethyl-4'-{[2-formyl-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-4-yl)acetate

Participants

Reaction Steps

According to a method similar to Example (40-2) and Example (8-3), from methyl (2-ethyl-4′-hydroxy-1,1′-biphenyl-4-yl)acetate (4.90 g, 18.1 mmol) obtained in Example (26-4) and 2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl methanesulfonate (8.35 g, 21.5 mmol) obtained in Example (26-5), methyl (2-ethyl-4′-{[2-formyl-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}-1,1′-biphenyl-4-yl)acetate was obtained as a colorless solid (6.77 g, two-step total yield: 79%).

Provenance & Evidence