HRID2076645

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21830928

N-(3-Iodophenyl)methanesulfonamide

C7H8INO2S

结构：CC(C)(C)OC(=O)c1c(COc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)ccc(C(F)(F)F)c1O

HCID67119153

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)c1c(COc2ccc(-c3cccc(NS(C)(=O)=O)c3)cc2)ccc(C(F)(F)F)c1O

HCID86617412

未命名化合物

PROCEDURE

实验过程

According to a method similar to Example (31), from N-(3-iodophenyl)methanesulfonamide (134 mg, 0.45 mmol) obtained in Example (35-1) and tert-butyl 2-hydroxy-6-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl}-3-(trifluoromethyl)benzoate (250 mg, 0.51 mmol) obtained in Example (22-4), the title compound was obtained as a pale violet powder (20 mg, yield: 8%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5b2c1707556247889dfe0565ce1247f1
来源数据集: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07923573B2
来源说明: uspto-grants-2011_04

反应 SMILES

I[C:2]1[CH:3]=[C:4]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[OH:13][C:14]1[C:26]([C:27]([F:30])([F:29])[F:28])=[CH:25][CH:24]=[C:23]([CH2:31][O:32][C:33]2[CH:38]=[CH:37][C:36](B3OC(C)(C)C(C)(C)O3)=[CH:35][CH:34]=2)[C:15]=1[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17]>>[OH:13][C:14]1[C:26]([C:27]([F:29])([F:30])[F:28])=[CH:25][CH:24]=[C:23]([CH2:31][O:32][C:33]2[CH:38]=[CH:37][C:36]([C:2]3[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:3]=3)=[CH:35][CH:34]=2)[C:15]=1[C:16]([O:18][C:19]([CH3:22])([CH3:20])[CH3:21])=[O:17]