N-(3-iodophenyl)methanesulfonamide → tert-Butyl 2-hydroxy-6-[({3'-[(methylsulfonyl)amino]-1,1'-biphenyl-4-yl}oxy)methyl]-3-(trifluromethyl)benzoate

HRID 2076645Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2076645
I[C:2]1[CH:3]=[C:4]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[OH:13][C:14]1[C:26]([C:27]([F:30])([F:29])[F:28])=[CH:25][CH:24]=[C:23]([CH2:31][O:32][C:33]2[CH:38]=[CH:37][C:36](B3OC(C)(C)C(C)(C)O3)=[CH:35][CH:34]=2)[C:15]=1[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17]>>[OH:13][C:14]1[C:26]([C:27]([F:29])([F:30])[F:28])=[CH:25][CH:24]=[C:23]([CH2:31][O:32][C:33]2[CH:38]=[CH:37][C:36]([C:2]3[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:3]=3)=[CH:35][CH:34]=2)[C:15]=1[C:16]([O:18][C:19]([CH3:22])([CH3:20])[CH3:21])=[O:17]

Komponenten

3

Edukt 2

HCID 21830928N-(3-iodophenyl)methanesulfonamideHCID 67119153Tert-butyl 2-hydroxy-6-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl}-3-(trifluoromethyl)benzoate

Produkt 1

HCID 86617412tert-Butyl 2-hydroxy-6-[({3'-[(methylsulfonyl)amino]-1,1'-biphenyl-4-yl}oxy)methyl]-3-(trifluromethyl)benzoate

Versuchsvorschrift

According to a method similar to Example (31), from N-(3-iodophenyl)methanesulfonamide (134 mg, 0.45 mmol) obtained in Example (35-1) and tert-butyl 2-hydroxy-6-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl}-3-(trifluoromethyl)benzoate (250 mg, 0.51 mmol) obtained in Example (22-4), the title compound was obtained as a pale violet powder (20 mg, yield: 8%).

Quellen und Nachweise

ORD-Eintrag
ord-5b2c1707556247889dfe0565ce1247f1
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07923573B2

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