Methyl (4'-hydroxy-2-isopropyl-1,1-biphenyl-4-yl)acetate → Methyl (4'-{[2-formyl-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}-2-isopropyl-1,1'-biphenyl-4-yl)acetate
Reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][C:15]([O:17][CH3:18])=[O:16])=[CH:10][C:9]=2[CH:19]([CH3:21])[CH3:20])=[CH:4][CH:3]=1.CS(O[CH2:27][C:28]1[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[C:30]([O:38]COC)[C:29]=1[CH:42](OC)[O:43]C)(=O)=O>>[CH:42]([C:29]1[C:30]([OH:38])=[C:31]([C:34]([F:35])([F:37])[F:36])[CH:32]=[CH:33][C:28]=1[CH2:27][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][C:15]([O:17][CH3:18])=[O:16])=[CH:10][C:9]=2[CH:19]([CH3:21])[CH3:20])=[CH:6][CH:7]=1)=[O:43]Participants
3
Procedure
According to a method similar to Example (40-2) and Example (8-3), from crudely purified methyl (4′-hydroxy-2-isopropyl-1,1-biphenyl-4-yl)acetate (147 mg) obtained in Example (42-3) and 2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl methanesulfonate (252 mg, 0.65 mmol) obtained in Example (26-5), crude methyl (4′-{[2-formyl-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}-2-isopropyl-1,1′-biphenyl-4-yl)acetate was obtained (169 mg).
Sources & evidence
- ORD record
- ord-6110d0de79b4460da5e73f5e84641186
- Source dataset
- uspto-grants-2011_04
- Patent number
- US07923573B2
Reaction notes
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