Methyl (4'-hydroxy-2-isopropyl-1,1-biphenyl-4-yl)acetate → Methyl (4'-{[2-formyl-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}-2-isopropyl-1,1'-biphenyl-4-yl)acetate

Participants

Reaction Steps

According to a method similar to Example (40-2) and Example (8-3), from crudely purified methyl (4′-hydroxy-2-isopropyl-1,1-biphenyl-4-yl)acetate (147 mg) obtained in Example (42-3) and 2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl methanesulfonate (252 mg, 0.65 mmol) obtained in Example (26-5), crude methyl (4′-{[2-formyl-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}-2-isopropyl-1,1′-biphenyl-4-yl)acetate was obtained (169 mg).

Provenance & Evidence