Tert-butyl 6-(bromomethyl)-3-methoxy-2-(methoxymethyl)benzoate → Tert-butyl 3-methoxy-2-(methoxymethoxy)-6-[({4'-[(methoxycarbonyl)methyl]-1,1'-biphenyl-4-yl}oxy)methyl]benzoate
Reaction equation
Br[CH2:2][C:3]1[C:8]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[C:7](COC)[C:6]([O:19][CH3:20])=[CH:5][CH:4]=1.[OH:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][C:31]([CH2:34][C:35]([O:37][CH3:38])=[O:36])=[CH:30][CH:29]=2)=[CH:24][CH:23]=1>>[CH3:20][O:19][C:6]1[C:7]([O:10][CH2:9][O:11][CH3:12])=[C:8]([C:3]([CH2:2][O:21][C:22]2[CH:23]=[CH:24][C:25]([C:28]3[CH:33]=[CH:32][C:31]([CH2:34][C:35]([O:37][CH3:38])=[O:36])=[CH:30][CH:29]=3)=[CH:26][CH:27]=2)=[CH:4][CH:5]=1)[C:9]([O:11][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:10]Participants
3
Procedure
According to a method similar to Example (40-2), from tert-butyl 6-(bromomethyl)-3-methoxy-2-(methoxymethyl)benzoate (1.20 g, 2.33 mmol) and methyl (4′-hydroxy-1,1′-biphenyl-4-yl)acetate (619 mg, 2.56 mmol) obtained in Example (6-2), tert-butyl 3-methoxy-2-(methoxymethoxy)-6-[({4′-[(methoxycarbonyl)methyl]-1,1′-biphenyl-4-yl}oxy)methyl]benzoate was obtained (306 mg, yield: 25%).
Sources & evidence
- ORD record
- ord-f0cf1297028d405784475f47162fbe4c
- Source dataset
- uspto-grants-2011_04
- Patent number
- US07923573B2
Reaction notes
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