N-[(3-Bromophenyl)methyl]methanesulfonamide → HCID 86617419, compound

HRID 2076667Notes

Reaction equation

HRID 2076667 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[CH2:5][NH:6][S:7]([CH3:10])(=[O:9])=[O:8].[OH:14][C:15]1[C:27]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:25]=[C:24]([CH2:32][O:33][C:34]2[CH:39]=[CH:38][C:37](B3OC(C)(C)C(C)(C)O3)=[CH:36][CH:35]=2)[C:16]=1[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18]>>[OH:14][C:15]1[C:27]([C:28]([F:30])([F:31])[F:29])=[CH:26][CH:25]=[C:24]([CH2:32][O:33][C:34]2[CH:39]=[CH:38][C:37]([C:2]3[CH:13]=[CH:12][CH:11]=[C:4]([CH2:5][NH:6][S:7]([CH3:10])(=[O:9])=[O:8])[CH:3]=3)=[CH:36][CH:35]=2)[C:16]=1[C:17]([O:19][C:20]([CH3:23])([CH3:21])[CH3:22])=[O:18]

Participants

3

Reactant 2

HCID 6464358N-[(3-Bromophenyl)methyl]methanesulfonamideHCID 67119153Tert-butyl 2-hydroxy-6-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl}-3-(trifluoromethyl)benzoate

Product 1

HCID 86617419HCID 86617419, compound

Procedure

According to a method similar to Example (31), from N-(3-bromobenzyl)methanesulfonamide (119 mg, 0.45 mmol) and tert-butyl 2-hydroxy-6-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl}-3-(trifluoromethyl)benzoate (250 mg, 0.51 mmol) obtained in Example (22-4), the title compound was obtained as a pale brown powder (49 mg, yield: 20%).

Sources & evidence

ORD record
ord-d9182f3deb13444e9d3c31272fc8613d
Source dataset
uspto-grants-2011_04
Patent number
US07923573B2

Reaction notes

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