HRID2076667

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6464358

N-[(3-Bromophenyl)methyl]methanesulfonamide

C8H10BrNO2S

结构：CC(C)(C)OC(=O)c1c(COc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)ccc(C(F)(F)F)c1O

HCID67119153

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)c1c(COc2ccc(-c3cccc(CNS(C)(=O)=O)c3)cc2)ccc(C(F)(F)F)c1O

HCID86617419

未命名化合物

PROCEDURE

实验过程

According to a method similar to Example (31), from N-(3-bromobenzyl)methanesulfonamide (119 mg, 0.45 mmol) and tert-butyl 2-hydroxy-6-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl}-3-(trifluoromethyl)benzoate (250 mg, 0.51 mmol) obtained in Example (22-4), the title compound was obtained as a pale brown powder (49 mg, yield: 20%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d9182f3deb13444e9d3c31272fc8613d
来源数据集: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07923573B2
来源说明: uspto-grants-2011_04

反应 SMILES

Br[C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[CH2:5][NH:6][S:7]([CH3:10])(=[O:9])=[O:8].[OH:14][C:15]1[C:27]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:25]=[C:24]([CH2:32][O:33][C:34]2[CH:39]=[CH:38][C:37](B3OC(C)(C)C(C)(C)O3)=[CH:36][CH:35]=2)[C:16]=1[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18]>>[OH:14][C:15]1[C:27]([C:28]([F:30])([F:31])[F:29])=[CH:26][CH:25]=[C:24]([CH2:32][O:33][C:34]2[CH:39]=[CH:38][C:37]([C:2]3[CH:13]=[CH:12][CH:11]=[C:4]([CH2:5][NH:6][S:7]([CH3:10])(=[O:9])=[O:8])[CH:3]=3)=[CH:36][CH:35]=2)[C:16]=1[C:17]([O:19][C:20]([CH3:23])([CH3:21])[CH3:22])=[O:18]