反应详情

A trimethylsilyldiazomethane-0.6M hexane solution (0.20 ml, 0.12 mmol) was added to a solution of (4′-{[2-(tert-butoxycarbonyl)-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}-3-chloro-1,1′-biphenyl-4-yl)acetic acid (60 mg, 0.11 mmol) obtained in Example (18-4) in a mixture of benzene-methanol (4:1, 2.5 ml), and the mixture was stirred for 1 hour. The residue obtained by removing the solvent under reduced pressure was purified by silica gel preparative thin layer chromatography (developing solvent: hexane/methylene chloride/ethyl acetate=9/1/1) to give the title compound (45 mg, yield: 73%).

1. customThe residue obtained
2. customby removing the solvent under reduced pressure
3. customwas purified by silica gel preparative thin layer chromatography (developing solvent: hexane/methylene chloride/ethyl acetate=9/1/1)