1,1,1-Trifluoro-2-propanol → HCID 86617423, compound

HRID 2076675Notes

Reaction equation

HRID 2076675 reaction equation
C([O:4][C:5]1[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:11]=[C:10]([CH2:18][O:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][C:29]([CH2:32][C:33]([O:35]CC=C)=[O:34])=[CH:28][CH:27]=3)=[CH:22][CH:21]=2)[C:6]=1[C:7]([OH:9])=[O:8])C=C.[F:39][C:40]([F:45])([F:44])[CH:41](O)[CH3:42]>>[OH:4][C:5]1[C:6]([C:7]([O:9][CH:41]([CH3:42])[C:40]([F:45])([F:44])[F:39])=[O:8])=[C:10]([CH:11]=[CH:12][C:13]=1[C:14]([F:15])([F:16])[F:17])[CH2:18][O:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[CH:31]=[CH:30][C:29]([CH2:32][C:33]([OH:35])=[O:34])=[CH:28][CH:27]=2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 97741,1,1-Trifluoro-2-propanolHCID 67119339HCID 67119339, compound

Product 1

HCID 86617423HCID 86617423, compoundYield 43%

Procedure

According to a method similar to Example (72-1) and Example (13-5), from 2-(allyloxy)-6-{[(4′-{[(allyloxy)carbonyl]methyl}-1,1′-biphenyl-4-yl)oxy]methyl}-3-(trifluoromethyl)benzoic acid (150 mg, 0.29 mmol) and 1,1,1-trifluoro-2-propanol (31 μl, 0.34 mmol), the title compound was obtained as a yellow crystal (68 mg, two-step total yield: 43%).

Sources & evidence

ORD record
ord-75e28738f6724711bb54e0494ec29d51
Source dataset
uspto-grants-2011_04
Patent number
US07923573B2

Reaction notes

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