Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate → HCID 67119110, compound
Reaction equation
Br[CH2:2][C:3]1[C:8]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[C:7]([O:16]C(OC(C)(C)C)=O)[C:6]([C:24]([F:27])([F:26])[F:25])=[CH:5][CH:4]=1.[OH:28][C:29]1[CH:34]=[CH:33][C:32]([C:35]2[CH:40]=[CH:39][C:38]([CH2:41][C:42]([O:44]C)=[O:43])=[CH:37][C:36]=2[CH:46]([OH:48])[CH3:47])=[CH:31][CH:30]=1>>[C:12]([O:11][C:9]([C:8]1[C:7]([OH:16])=[C:6]([C:24]([F:27])([F:26])[F:25])[CH:5]=[CH:4][C:3]=1[CH2:2][O:28][C:29]1[CH:30]=[CH:31][C:32]([C:35]2[CH:40]=[CH:39][C:38]([CH2:41][C:42]([OH:44])=[O:43])=[CH:37][C:36]=2[CH:46]([OH:48])[CH3:47])=[CH:33][CH:34]=1)=[O:10])([CH3:14])([CH3:15])[CH3:13]Participants
3
Procedure
According to a method similar to Example (40-2), Example (33-5) and Example (17-4), from tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (137 mg, 0.325 mmol) obtained in Example (28-5) and methyl [4′-hydroxy-2-(1-hydroxyethyl)-1,1′-biphenyl-4-yl]acetate (93 mg, 0.325 mmol) obtained in Example (88-1), the title compound was obtained as a pale yellow oil (60 mg, yield: 34%).
Sources & evidence
- ORD record
- ord-fd67cb86807b4c77b71e4f8887c50e9e
- Source dataset
- uspto-grants-2011_04
- Patent number
- US07923573B2
Reaction notes
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