反应详情

Chloromethyl methyl ether (0.5 ml, 6.59 mmol) and diisopropylethylamine (1.44 ml, 8.24 mmol) were added to a solution of 4′-hydroxy-1,1′-biphenyl-4-carbonitrile (1.07 g, 5.49 mmol) in methylene chloride (10 ml), and the mixture was stirred at room temperature for 16 hours. After water was added to the reaction mixture and the mixture was extracted with ethyl acetate, the organic layer was washed with a saturated aqueous NaCl solution and dried with anhydrous sodium sulfate. The residue obtained by removing the solvent under reduced pressure was purified by silica gel column chromatography (developing solvent: hexane/ethyl acetate=5/1) to give 4′-methoxymethoxy-1,1′-biphenyl-4-carbonitrile (1.03 g, yield: 78%).

1. extractionthe mixture was extracted with ethyl acetate
2. washthe organic layer was washed with a saturated aqueous NaCl solution
3. dry with materialdried with anhydrous sodium sulfate
4. customThe residue obtained
5. customby removing the solvent under reduced pressure
6. customwas purified by silica gel column chromatography (developing solvent: hexane/ethyl acetate=5/1)