HCID 67119141, compound → HCID 67119247, compound

HRID 2076709Notes

Reaction equation

HRID 2076709 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH:14]([CH3:19])[C:15]([O:17]C)=[O:16])=[CH:10][C:9]=2[CH3:20])=[CH:4][CH:3]=1.Br[CH2:22][C:23]1[C:28]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[C:27]([O:36]C(OC(C)(C)C)=O)[C:26]([C:44]([F:47])([F:46])[F:45])=[CH:25][CH:24]=1>>[C:32]([O:31][C:29]([C:28]1[C:27]([OH:36])=[C:26]([C:44]([F:46])([F:47])[F:45])[CH:25]=[CH:24][C:23]=1[CH2:22][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH:14]([CH3:19])[C:15]([OH:17])=[O:16])=[CH:10][C:9]=2[CH3:20])=[CH:6][CH:7]=1)=[O:30])([CH3:35])([CH3:33])[CH3:34]

Participants

3

Reactant 2

HCID 67119141HCID 67119141, compoundHCID 67119234Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate

Product 1

HCID 67119247HCID 67119247, compoundYield 53%

Procedure

According to a method similar to Example (2-3), Example (33-5) and Example (17-4), from methyl 2-(4′-hydroxy-2-methyl-1,1′-biphenyl-4-yl)propanoate (224 mg, 0.83 mmol) obtained in Example (107-1) and tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (415 mg, 0.91 mmol) obtained in Example (28-5), the title compound was obtained as a colorless powder (235 mg, three-step total yield: 53%).

Sources & evidence

ORD record
ord-2badfeecab4d4b2780851f629217f2fe
Source dataset
uspto-grants-2011_04
Patent number
US07923573B2

Reaction notes

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