HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67119141, compound → HCID 67119247, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67119141 | HCID 67119141 | — |
| Reactant | Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate | HCID 67119234 | — |
| Product | HCID 67119247 | HCID 67119247 | 53% |
Reaction Steps
According to a method similar to Example (2-3), Example (33-5) and Example (17-4), from methyl 2-(4′-hydroxy-2-methyl-1,1′-biphenyl-4-yl)propanoate (224 mg, 0.83 mmol) obtained in Example (107-1) and tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (415 mg, 0.91 mmol) obtained in Example (28-5), the title compound was obtained as a colorless powder (235 mg, three-step total yield: 53%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07923573B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-2badfeecab4d4b2780851f629217f2fe |
| Source note | uspto-grants-2011_04 |