Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate → HCID 11664063, compound

HRID 2076711Notes

Reaction equation

HRID 2076711 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH:14]([CH3:19])[C:15]([O:17]C)=[O:16])=[CH:10][C:9]=2[CH:20]([CH3:22])[CH3:21])=[CH:4][CH:3]=1.Br[CH2:24][C:25]1[C:30]([C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])=[C:29]([O:38]C(OC(C)(C)C)=O)[C:28]([C:46]([F:49])([F:48])[F:47])=[CH:27][CH:26]=1>>[C:34]([O:33][C:31]([C:30]1[C:29]([OH:38])=[C:28]([C:46]([F:49])([F:47])[F:48])[CH:27]=[CH:26][C:25]=1[CH2:24][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH:14]([CH3:19])[C:15]([OH:17])=[O:16])=[CH:10][C:9]=2[CH:20]([CH3:22])[CH3:21])=[CH:6][CH:7]=1)=[O:32])([CH3:37])([CH3:36])[CH3:35]

Participants

3

Reactant 2

HCID 67119234Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoateHCID 67119384HCID 67119384, compound

Product 1

HCID 11664063HCID 11664063, compoundYield 45%

Procedure

According to a method similar to Example (2-3), Example (33-5) and Example (17-4), from methyl 2-(4′-hydroxy-2-isopropyl-1,1′-biphenyl-4-yl)propanoate (290 mg, 0.97 mmol) obtained in Example (107-1) and tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (487 mg, 1.07 mmol) obtained in Example (28-5), the title compound was obtained as a colorless powder (246 mg, three-step total yield: 45%).

Sources & evidence

ORD record
ord-a538d193458245208cbc1dc4aaccef31
Source dataset
uspto-grants-2011_04
Patent number
US07923573B2

Reaction notes

Loading…