Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate → HCID 11664063, compound

Participants

Reaction Steps

According to a method similar to Example (2-3), Example (33-5) and Example (17-4), from methyl 2-(4′-hydroxy-2-isopropyl-1,1′-biphenyl-4-yl)propanoate (290 mg, 0.97 mmol) obtained in Example (107-1) and tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (487 mg, 1.07 mmol) obtained in Example (28-5), the title compound was obtained as a colorless powder (246 mg, three-step total yield: 45%).

Provenance & Evidence