Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate → HCID 67119365, compound

HRID 2076712Notes

Reaction equation

HRID 2076712 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([CH:9]([CH3:14])[C:10]([O:12]C)=[O:11])[CH:5]=[CH:4][C:3]=1[C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1.Br[CH2:23][C:24]1[C:29]([C:30]([O:32]C(C)(C)C)=[O:31])=[C:28]([O:37]C(OC(C)(C)C)=O)[C:27]([C:45]([F:48])([F:47])[F:46])=[CH:26][CH:25]=1>>[C:3]([O:32][C:30]([C:29]1[C:28]([OH:37])=[C:27]([C:45]([F:46])([F:48])[F:47])[CH:26]=[CH:25][C:24]=1[CH2:23][O:21][C:18]1[CH:19]=[CH:20][C:15]([C:3]2[CH:4]=[CH:5][C:6]([CH:9]([CH3:14])[C:10]([OH:12])=[O:11])=[C:7]([F:8])[C:2]=2[F:1])=[CH:16][CH:17]=1)=[O:31])([CH3:15])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 67119234Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoateHCID 67119269HCID 67119269, compound

Product 1

HCID 67119365HCID 67119365, compound

Procedure

According to a method similar to Example (40-2), Example (33-5) and Example (17-4), from methyl 2-(2,3-difluoro-4′-hydroxy-1,1′-biphenyl-4-yl)propanoate (193 mg, 0.661 mmol) and tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (306 mg, 0.726 mmol) obtained in Example (28-5), the title compound was obtained as a white powder (45 mg, yield: 12%).

Sources & evidence

ORD record
ord-fd99ab9fb39a404ab0e6988b5e50ca05
Source dataset
uspto-grants-2011_04
Patent number
US07923573B2

Reaction notes

Loading…