HCID 67119094, compound → HCID 11592117, compound

HRID 2076713Notes

Reaction equation

HRID 2076713 reaction equation
[CH:1]1([C:4]2[CH:9]=[C:8]([CH:10]([CH3:15])[C:11]([O:13]C)=[O:12])[CH:7]=[CH:6][C:5]=2[C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)[CH2:3][CH2:2]1.Br[CH2:24][C:25]1[C:30]([C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])=[C:29]([O:38]C(OC(C)(C)C)=O)[C:28]([C:46]([F:49])([F:48])[F:47])=[CH:27][CH:26]=1>>[C:34]([O:33][C:31]([C:30]1[C:29]([OH:38])=[C:28]([C:46]([F:48])([F:47])[F:49])[CH:27]=[CH:26][C:25]=1[CH2:24][O:22][C:19]1[CH:18]=[CH:17][C:16]([C:5]2[CH:6]=[CH:7][C:8]([CH:10]([CH3:15])[C:11]([OH:13])=[O:12])=[CH:9][C:4]=2[CH:1]2[CH2:2][CH2:3]2)=[CH:21][CH:20]=1)=[O:32])([CH3:37])([CH3:36])[CH3:35]

Participants

3

Reactant 2

HCID 67119094HCID 67119094, compoundHCID 67119234Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate

Product 1

HCID 11592117HCID 11592117, compoundYield 45%

Procedure

According to a method similar to Example (2-3), Example (33-5) and Example (17-4), from methyl 2-(2-cyclopropyl-4′-hydroxy-1,1′-biphenyl-4-yl)propanoate (135 mg, 0.46 mmol) obtained in Example (112-1) and tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (249 mg, 0.55 mmol) obtained in Example (28-5), the title compound was obtained as a colorless powder (115 mg, three-step total yield: 45%).

Sources & evidence

ORD record
ord-8101d74bccc54451b7b1eb0223de6f96
Source dataset
uspto-grants-2011_04
Patent number
US07923573B2

Reaction notes

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