HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67119094, compound → HCID 11592117, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67119094 | HCID 67119094 | — |
| Reactant | Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate | HCID 67119234 | — |
| Product | HCID 11592117 | HCID 11592117 | 45% |
Reaction Steps
According to a method similar to Example (2-3), Example (33-5) and Example (17-4), from methyl 2-(2-cyclopropyl-4′-hydroxy-1,1′-biphenyl-4-yl)propanoate (135 mg, 0.46 mmol) obtained in Example (112-1) and tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (249 mg, 0.55 mmol) obtained in Example (28-5), the title compound was obtained as a colorless powder (115 mg, three-step total yield: 45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07923573B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-8101d74bccc54451b7b1eb0223de6f96 |
| Source note | uspto-grants-2011_04 |