Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate → Tert-butyl 2-[(tert-butoxycarbonyl)oxy]-6-[({2'-methoxy-3'-[(methoxycarbonyl)methyl]-1,1'-biphenyl-4-yl}oxy)methyl]-3-(trifluoromethyl)benzoate
Reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[C:9]=2[O:19][CH3:20])=[CH:4][CH:3]=1.Br[CH2:22][C:23]1[C:28]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[C:27]([O:36][C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[C:26]([C:44]([F:47])([F:46])[F:45])=[CH:25][CH:24]=1>>[C:40]([O:39][C:37]([O:36][C:27]1[C:26]([C:44]([F:45])([F:46])[F:47])=[CH:25][CH:24]=[C:23]([CH2:22][O:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[C:9]=3[O:19][CH3:20])=[CH:6][CH:7]=2)[C:28]=1[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[O:38])([CH3:41])([CH3:42])[CH3:43]Participants
3
Reactant 2
Product 1
Procedure
According to a method similar to Example (2-3), from methyl (4′-hydroxy-2-methoxy-1,1′-biphenyl-3-yl)acetate (792 mg, 2.91 mmol) obtained in Example (114-1) and tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (1.32 g, 2.91 mmol) obtained in Example (28-5), tert-butyl 2-[(tert-butoxycarbonyl)oxy]-6-[({2′-methoxy-3′-[(methoxycarbonyl)methyl]-1,1′-biphenyl-4-yl}oxy)methyl]-3-(trifluoromethyl)benzoate was obtained as a yellow oil (1.20 g, yield: 64%).
Sources & evidence
- ORD record
- ord-a0fb81dbb51f42ba9b28346d6a68941d
- Source dataset
- uspto-grants-2011_04
- Patent number
- US07923573B2
Reaction notes
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