HRID2076714

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)Oc1c(C(F)(F)F)ccc(CBr)c1C(=O)OC(C)(C)C

HCID67119234

未命名化合物

HCID86241535

未命名化合物

PRODUCTS

生成物

结构：COC(=O)Cc1cccc(-c2ccc(OCc3ccc(C(F)(F)F)c(OC(=O)OC(C)(C)C)c3C(=O)OC(C)(C)C)cc2)c1OC

HCID67119214

未命名化合物

PROCEDURE

实验过程

According to a method similar to Example (2-3), from methyl (4′-hydroxy-2-methoxy-1,1′-biphenyl-3-yl)acetate (792 mg, 2.91 mmol) obtained in Example (114-1) and tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (1.32 g, 2.91 mmol) obtained in Example (28-5), tert-butyl 2-[(tert-butoxycarbonyl)oxy]-6-[({2′-methoxy-3′-[(methoxycarbonyl)methyl]-1,1′-biphenyl-4-yl}oxy)methyl]-3-(trifluoromethyl)benzoate was obtained as a yellow oil (1.20 g, yield: 64%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a0fb81dbb51f42ba9b28346d6a68941d
来源数据集: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07923573B2
来源说明: uspto-grants-2011_04

反应 SMILES

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[C:9]=2[O:19][CH3:20])=[CH:4][CH:3]=1.Br[CH2:22][C:23]1[C:28]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[C:27]([O:36][C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[C:26]([C:44]([F:47])([F:46])[F:45])=[CH:25][CH:24]=1>>[C:40]([O:39][C:37]([O:36][C:27]1[C:26]([C:44]([F:45])([F:46])[F:47])=[CH:25][CH:24]=[C:23]([CH2:22][O:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[C:9]=3[O:19][CH3:20])=[CH:6][CH:7]=2)[C:28]=1[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[O:38])([CH3:41])([CH3:42])[CH3:43]