Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate → Tert-butyl 2-[(tert-butoxycarbonyl)oxy]-6-[({2'-methoxy-3'-[(methoxycarbonyl)methyl]-1,1'-biphenyl-4-yl}oxy)methyl]-3-(trifluoromethyl)benzoate

Participants

Reaction Steps

According to a method similar to Example (2-3), from methyl (4′-hydroxy-2-methoxy-1,1′-biphenyl-3-yl)acetate (792 mg, 2.91 mmol) obtained in Example (114-1) and tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (1.32 g, 2.91 mmol) obtained in Example (28-5), tert-butyl 2-[(tert-butoxycarbonyl)oxy]-6-[({2′-methoxy-3′-[(methoxycarbonyl)methyl]-1,1′-biphenyl-4-yl}oxy)methyl]-3-(trifluoromethyl)benzoate was obtained as a yellow oil (1.20 g, yield: 64%).

Provenance & Evidence