Carbamazepine → HCID 67107456, compound

HRID 2076726Notes

Reaction equation

HRID 2076726 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[N:15]([C:16]([NH2:18])=[O:17])[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[CH:8]=[CH:7][C:5]=2[CH:6]=1.[N:19]1[C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=[CH:21][C:20]=1[C:28]([OH:30])=[O:29]>C(O)C>[CH:11]1[CH:12]=[CH:13][C:14]2[N:15]([C:16]([NH2:18])=[O:17])[C:4]3[CH:3]=[CH:2][CH:1]=[CH:6][C:5]=3[CH:7]=[CH:8][C:9]=2[CH:10]=1.[N:19]1[C:20]([C:28]([OH:30])=[O:29])=[CH:21][CH:22]=[CH:23][C:24]=1[C:25]([OH:27])=[O:26]

Participants

4

Reactant 2

HCID 2554CarbamazepineHCID 103672,6-Pyridinedicarboxylic acid

Product 1

HCID 67107456HCID 67107456, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

36 mg (0.1524 mmol) carbamazepine and 26 mg (0.1556 mmol) 2,6-pyridinedicarboxylic acid were dissolved in approximately 2 mL ethanol. Slow evaporation of the solvent yielded clear needles of a 1:1 carbamazepine/2,6-pyridinedicarboxylic acid co-crystal, as shown in FIG. 54A-B.

Workup

  1. customevaporation of the solvent

Sources & evidence

ORD record
ord-69fc570bbe844cc3b8190e9f7c9ca3de
Source dataset
uspto-grants-2011_04
Patent number
US07927613B2

Reaction notes

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