Ethanol → HCID 67107880, compound

HRID 2076727Notes

Reaction equation

HRID 2076727 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[N:15]([C:16]([NH2:18])=[O:17])[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[CH:8]=[CH:7][C:5]=2[CH:6]=1.[N+:19]([C:22]1[CH:23]=[C:24]([C:31]([OH:33])=[O:32])[CH:25]=[C:26]([CH:30]=1)[C:27]([OH:29])=[O:28])([O-:21])=[O:20].C(O)C>CO>[CH:11]1[CH:12]=[CH:13][C:14]2[N:15]([C:16]([NH2:18])=[O:17])[C:4]3[CH:3]=[CH:2][CH:1]=[CH:6][C:5]=3[CH:7]=[CH:8][C:9]=2[CH:10]=1.[N+:19]([C:22]1[CH:23]=[C:24]([C:31]([OH:33])=[O:32])[CH:25]=[C:26]([CH:30]=1)[C:27]([OH:29])=[O:28])([O-:21])=[O:20]

Participants

5

Reactant 3

HCID 702EthanolHCID 2554CarbamazepineHCID 120695-Nitroisophthalic acid

Product 1

HCID 67107880HCID 67107880, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

40 mg (0.1693 mmol) carbamazepine and 30 mg (0.1421 mmol) 5-nitroisophthalic acid were dissolved in approximately 3 mL methanol or ethanol. Slow evaporation of the solvent yielded yellow needles of a 1:1 carbamazepine/5-nitroisophthalic acid co-crystal, as shown in FIG. 55A-B.

Workup

  1. customevaporation of the solvent

Sources & evidence

ORD record
ord-664a081a31954368a8196399dc1d5b5d
Source dataset
uspto-grants-2011_04
Patent number
US07927613B2

Reaction notes

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