Ethanol → HCID 67547676, compound

HRID 2076728Notes

Reaction equation

HRID 2076728 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[N:15]([C:16]([NH2:18])=[O:17])[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[CH:8]=[CH:7][C:5]=2[CH:6]=1.[C:19]12([C:38]([OH:40])=[O:39])[CH2:31][C:23]3([C:32]([OH:34])=[O:33])[CH2:24][C:25]([C:28]([OH:30])=[O:29])([CH2:27][C:21]([C:35]([OH:37])=[O:36])([CH2:22]3)[CH2:20]1)[CH2:26]2.C(O)C>CO>[CH:11]1[CH:12]=[CH:13][C:14]2[N:15]([C:16]([NH2:18])=[O:17])[C:4]3[CH:3]=[CH:2][CH:1]=[CH:6][C:5]=3[CH:7]=[CH:8][C:9]=2[CH:10]=1.[C:21]12([C:35]([OH:37])=[O:36])[CH2:20][C:19]3([C:38]([OH:40])=[O:39])[CH2:26][C:25]([C:28]([OH:30])=[O:29])([CH2:24][C:23]([C:32]([OH:34])=[O:33])([CH2:31]3)[CH2:22]1)[CH2:27]2

Participants

5

Reactant 3

HCID 702EthanolHCID 2554CarbamazepineHCID 6224951,3,5,7-Adamantanetetracarboxylic acid

Product 1

HCID 67547676HCID 67547676, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

15 mg (0.1524 mmol) carbamazepine and 20 mg (0.1556 mmol) 1,3,5,7-adamantanetetracarboxylic acid were dissolved in approximately 1 mL methanol or 1 mL ethanol. Slow evaporation of the solvent yields clear plates of a 2:1 carbamazepine/1,3,5,7-adamantanetetracarboxylic acid co-crystal, as shown in FIG. 56A-B.

Workup

  1. customevaporation of the solvent

Sources & evidence

ORD record
ord-4a4a81456b774528a6f5692e987eca0f
Source dataset
uspto-grants-2011_04
Patent number
US07927613B2

Reaction notes

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