Carbamazepine → HCID 131728783, compound

HRID 2076730Notes

Reaction equation

HRID 2076730 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[N:15]([C:16]([NH2:18])=[O:17])[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[CH:8]=[CH:7][C:5]=2[CH:6]=1.[C:19]([OH:33])(=[O:32])[C:20]1[CH:31]=[C:27]([C:28]([OH:30])=[O:29])[CH:26]=[C:22]([C:23]([OH:25])=[O:24])[CH:21]=1>CO.ClCCl>[CH:11]1[CH:12]=[CH:13][C:14]2[N:15]([C:16]([NH2:18])=[O:17])[C:4]3[CH:3]=[CH:2][CH:1]=[CH:6][C:5]=3[CH:7]=[CH:8][C:9]=2[CH:10]=1.[C:19]([OH:33])(=[O:32])[C:20]1[CH:21]=[C:22]([C:23]([OH:25])=[O:24])[CH:26]=[C:27]([C:28]([OH:30])=[O:29])[CH:31]=1

Participants

5

Reactant 2

HCID 2554CarbamazepineHCID 111381,3,5-Benzenetricarboxylic acid

Product 1

HCID 131728783HCID 131728783, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

36 mg (0.1524 mmol) carbamazepine and 31 mg (0.1475 mmol) trimesic acid were dissolved in a solvent mixture of approximately 2 mL methanol and 2 mL dichloromethane. Slow evaporation of the solvent mixture yielded white starbursts of a 1:1 carbamazepine/trimesic acid co-crystal, as shown in FIG. 58A-B.

Workup

  1. customevaporation of the solvent mixture

Sources & evidence

ORD record
ord-6416a4aeec8943aabd6bb6df8014258e
Source dataset
uspto-grants-2011_04
Patent number
US07927613B2

Reaction notes

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