Trifluoroacetic acid → Trifluoroacetate

HRID 2076794Notes

Reaction equation

HRID 2076794 reaction equation
C(OC(=O)[NH:7][C@@:8]([CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[CH:18][CH:17]=1)([CH3:13])[C@H:9]([OH:12])[CH2:10][CH3:11])(C)(C)C.[C:31]([OH:37])([C:33]([F:36])([F:35])[F:34])=[O:32]>C(Cl)Cl>[NH2:7][C@:8]([CH3:13])([CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[CH:20][CH:21]=1)[C@H:9]([OH:12])[CH2:10][CH3:11].[F:34][C:33]([F:36])([F:35])[C:31]([O-:37])=[O:32]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67099209HCID 67099209, compound

Product 2

HCID 84468TrifluoroacetateHCID 11515289HCID 11515289, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of {(1R,2R)-1-[2-(4-Heptyloxy-phenyl)-ethyl]-2-hydroxy-1-methyl-butyl}-carbamic acid tert-butyl ester (25 mg, 0.06 mMol) in CH2Cl2 (3 ml) is added TFA (0.3 ml). The solution is stirred at RT for 2 hours. After removing the solvent under reduced pressure, the residue is lyophilized from dioxane to give the title compound as its trifluoroacetate salt as a white, amorphous powder.

Workup

  1. customAfter removing the solvent under reduced pressure

Sources & evidence

ORD record
ord-28c817bb49c54921a0994c13661afc13
Source dataset
uspto-grants-2011_04
Patent number
US07928093B2

Reaction notes

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