反应详情

6-Oxo-1,6-dihydro-[1,2,4]triazine-5-carboxylic acid ethyl ester (115 mg, 0.68 mmol) in POCl3 (1.5 ml) was heated to 100° C. for 2 h. All volatiles were then removed and the remaining residue was diluted with cold CHCl3 and carefully neutralized with sat. NaHCO3-solution. This mixture was extracted with cold CHCl3. The organic phase was then washed with cold brine, dried (Na2SO4) and evaporated to give the crude title compound (115 mg, 90%) as brown gum, which was used in the next reaction step without further purification. MS: m/e=188.2 [M+H+].

1. customAll volatiles were then removed
2. additionthe remaining residue was diluted with cold CHCl3
3. extractionThis mixture was extracted with cold CHCl3
4. washThe organic phase was then washed with cold brine
5. dry with materialdried (Na2SO4)
6. customevaporated