HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → benzyl N-[2-[(3-chloropyrazine-2-carbonyl)amino]-2-iminoethyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzyl 2-amino-2-iminoethylcarbamate | HCID 244144 | — |
| Reactant | 3-Chloro-2-pyrazine-carboxylic acid | HCID 1501900 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | benzyl N-[2-[(3-chloropyrazine-2-carbonyl)amino]-2-iminoethyl]carbamate | HCID 140529508 | — |
Reaction Steps
Under an atmosphere of nitrogen, 3-chloro-2-pyrazinecarboxylic acid (76 mg), TBTU (168 mg), and diisopropylethylamine (310 mg) were added to a solution of carbamimidoylmethyl-carbamic acid benzyl ester [77390-81-9] (99 mg) in DMF (6 ml). The reaction mixture was stirred for 2 h at ambient temperature, diluted with dichloromethane and washed with water. The organic layer was dried (Na2SO4), filtered, and the solvent was evaporated. The obtained, crude title compound (220 mg) was used without further purification in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07928106B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-c59ee54533064021b929864651a17e2e |
| Source note | uspto-grants-2011_04 |