2-Phenylethane-1-sulfonyl chloride → 2-Phenyl-ethanesulfonic acid (4-oxo-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-ylmethyl)-amide

HRID 2076838Notes

Reaction equation

HRID 2076838 reaction equation
[NH2:1][CH2:2][C:3]1[NH:4][C:5](=[O:13])[C:6]2[C:7]([N:12]=1)=[N:8][CH:9]=[N:10][CH:11]=2.[C:14]1([CH2:20][CH2:21][S:22](Cl)(=[O:24])=[O:23])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[O:13]=[C:5]1[C:6]2[C:7](=[N:8][CH:9]=[N:10][CH:11]=2)[N:12]=[C:3]([CH2:2][NH:1][S:22]([CH2:21][CH2:20][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(=[O:24])=[O:23])[NH:4]1

Participants

3

Reactant 2

HCID 27603742-Phenylethane-1-sulfonyl chlorideHCID 136366828HCID 136366828, compound

Product 1

HCID 1359235502-Phenyl-ethanesulfonic acid (4-oxo-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-ylmethyl)-amide

Procedure

In analogy to the procedure described in example 20.4, 2-aminomethyl-3H-pyrimido[4,5-d]pyrimidin-4-one (example 20.3) was treated with 2-phenyl-ethanesulfonyl chloride [4025-71-2] to obtain 2-phenyl-ethanesulfonic acid (4-oxo-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-ylmethyl)-amide as light brown solid. MS: m/e=346.3 [M+H+].

Sources & evidence

ORD record
ord-8b969d85a39e4a61a31557f80d1956d9
Source dataset
uspto-grants-2011_04
Patent number
US07928106B2

Reaction notes

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