Dichloromethane → 4-(2-Methylindol-5-yloxy)-7-(piperidin-4-ylmethoxy)quinazoline

HRID 207690Notes

Reaction equation

HRID 207690 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][O:15][c:16]2[cH:17][cH:18][c:19]3[c:20]([O:26][c:27]4[cH:28][c:29]5[cH:30][c:31]([CH3:36])[nH:32][c:33]5[cH:34][cH:35]4)[n:21][cH:22][n:23][c:24]3[cH:25]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH2:37]([Cl:38])[Cl:39].[F:40][C:41]([F:42])([F:43])[C:44]([OH:45])=[O:46]>>[NH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][O:15][c:16]2[cH:17][cH:18][c:19]3[c:20]([O:26][c:27]4[cH:28][c:29]5[cH:30][c:31]([CH3:36])[nH:32][c:33]5[cH:34][cH:35]4)[n:21][cH:22][n:23][c:24]3[cH:25]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 220308467-(1-Tert-butoxycarbonylpiperidin-4-ylmethoxy)-4-(2-methylindol-5-yloxy)quinazoline

Product 1

HCID 220308754-(2-Methylindol-5-yloxy)-7-(piperidin-4-ylmethoxy)quinazoline

Sources & evidence

ORD record
ord-c146064a06364109aa87d258cf87ebdb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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