Hydroxylamine → 2-(Hydroxyamino)quinazolin-4-amine

HRID 2076988Notes

Reaction equation

HRID 2076988 reaction equation
Cl[C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:13][OH:14]>>[OH:14][NH:13][C:2]1[N:11]=[C:10]([NH2:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 787HydroxylamineHCID 2528792-Chloroquinazolin-4-amine

Product 1

HCID 574569202-(Hydroxyamino)quinazolin-4-amine

Procedure

Prepared as in Example 42 from 2-chloroquinazolin-4-amine (Example 38) and hydroxylamine. 1H NMR (400 MHz, DMSO-d6) δ 7.44-7.35 (m, 2H), 7.78-7.74 (m, 2H), 8.24-8.22 (m, 1H), 8.95-8.76 (m, 2H). MS 177 (MH+).

Sources & evidence

ORD record
ord-c7cbcbdc14494aaa973bf44f223a8c4f
Source dataset
uspto-grants-2011_04
Patent number
US07928111B2

Reaction notes

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