Benzeneethanimidamide → Tert-butyl 2-benzyl-9-methyl-4-oxo-3,4,5,6,8,9-hexahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate

HRID 2077049Notes

Reaction equation

HRID 2077049 reaction equation
[CH3:1][CH:2]1[CH2:8][N:7]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:6][CH2:5][CH:4]([C:16]([O:18]CC)=O)[C:3]1=O.[C:22]1([CH2:28][C:29]([NH2:31])=[NH:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[CH2:28]([C:29]1[NH:31][C:16](=[O:18])[C:4]2[CH2:5][CH2:6][N:7]([C:9]([O:11][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:10])[CH2:8][CH:2]([CH3:1])[C:3]=2[N:30]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 27787BenzeneethanimidamideHCID 593122241-Tert-butyl 4-ethyl 6-methyl-5-oxoazepane-1,4-dicarboxylate

Product 1

HCID 136058087Tert-butyl 2-benzyl-9-methyl-4-oxo-3,4,5,6,8,9-hexahydro-7H-pyrimido[4,5-d]azepine-7-carboxylateYield 70%

Procedure

The title compound was prepared by a similar method to that of Preparation 1, Step A, starting from 1-tert-butyl 4-ethyl 6-methyl-5-oxoazepane-1,4-dicarboxylate and 2-phenyl-acetamidine, yielding 70% of title compound.

Workup

  1. customThe title compound was prepared by a similar method to that
  2. customof Preparation 1, Step A

Sources & evidence

ORD record
ord-e7cb177616d94d0fa3a9b1e1692cbbc8
Source dataset
uspto-grants-2011_04
Patent number
US07928099B2

Reaction notes

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